The aerodynamic challenges of SRB recovery

Recovery and reuse of the Space Shuttle solid rocket boosters was baselined to support the primary goal to develop a low cost space transportation system. The recovery system required for the 170,000-lb boosters was for the largest and heaviest object yet to be retrieved from exoatmospheric conditions. State-of-the-art design procedures were ground-ruled and development testing minimized to produce both a reliable and cost effective system. The ability to utilize the inherent drag of the boosters during the initial phase of reentry was a key factor in minimizing the parachute loads, size and weight. A wind tunnel test program was devised to enable the accurate prediction of booster aerodynamic characteristics. Concurrently, wind tunnel, rocket sled and air drop tests were performed to develop and verify the performance of the parachute decelerator subsystem. Aerodynamic problems encountered during the overall recovery system development and the respective solutions are emphasized

Mars Lander Vehicle/Parachute Dynamics

Parachute decelerators used exclusively or in combination with retro rockets have been considered prime candidates for the terminal descent and landing system of a scientifically instrumented Mars lander. The objective of this study is to understand basic relationships between parameters affecting dynamic response of the parachute and capsule and to define those aspects of the system which have a sensitive effect on the design of the lander capsule. Of particular interest is the response of the capsule to wind gusts and to establish the sensitivity to gust onset rates in the VM series of Martian atmospheres. The model used in studying parachute/capsule relationships consists of two bodies, each with three degrees-of-freedom, connected by an elastic riser cable. The total elastic nature of the parachute and shroud lines is simulated by the equivalent elasticity of the riser cable. The parachute and its enclosed and apparent inertia effects are treated in a rigid body sense. Parachute opening phase dynamics are included in the analysis model. Motion of the system is examined in either the pitch or yaw plane with roll motion assumed to be controlled near zero by an attitude control system. Capsule attitude excursions and attitude rates are investigated in detail because of their impact on optical and radar sensors. The ability of a simple rate damping attitude control system to combat capsule oscillations is included in the study. Usually a planetary entry vehicle utilizes a blunt body aeroshell coated with ablative material for the high dynamic pressure, high Mach number portion of the entry trajectory. Once this region has been traversed and Mach number is reduced to approximately 1.6, the parachute decelerator may be deployed. From this point on, the aeroshell serves little usefulness and may complicate the touchdown mechanics. It may be desirable, therefore to jettison the aeroshell as soon as possible after parachute deployment. The ease of accomplishing aeroshell separation while descending on a parachute is evaluated

Video guidance, landing, and imaging systems

The adaptive potential of video guidance technology for earth orbital and interplanetary missions was explored. The application of video acquisition, pointing, tracking, and navigation technology was considered to three primary missions: planetary landing, earth resources satellite, and spacecraft rendezvous and docking. It was found that an imaging system can be mechanized to provide a spacecraft or satellite with a considerable amount of adaptability with respect to its environment. It also provides a level of autonomy essential to many future missions and enhances their data gathering ability. The feasibility of an autonomous video guidance system capable of observing a planetary surface during terminal descent and selecting the most acceptable landing site was successfully demonstrated in the laboratory. The techniques developed for acquisition, pointing, and tracking show promise for recognizing and tracking coastlines, rivers, and other constituents of interest. Routines were written and checked for rendezvous, docking, and station-keeping functions

Balloon launched Viking decelerator test program

Four BLDT flights were conducted during the summer of 1972. The purpose of these tests was to qualify the Viking parachute system behind the full-scale Viking entry vehicle over the maximum range of entry conditions anticipated in the Viking '75 soft landing on Mars. A summary of the test series is presented. Test conditions ranged from a Mach number of 2.0 to 0.5 and dynamic pressure from 11.7 to 4.4 psf. This range of conditions covers the uncertainty in entry conditions at Mars due to atmospheric and entry performance uncertainties. Emphasis is placed on parachute performance and simulated Mars entry vehicle motions as influenced by the parachute performance. Conclusions are presented regarding the ability of the parachute to perform within the operational parameters required for a successful soft Martian landing. A list of references which covers all reports in the qualification test program is included

Literacy outcomes for Deaf and Hard of Hearing primary school children: A cohort comparison study

Purpose: This study compared the language and literacy of two cohorts of children with severe-profound hearing loss, recruited 10 years apart, to determine whether outcomes had improved in line with the introduction of newborn hearing screening and access to improved hearing aid technology. Method: Forty-two deaf children, aged 5 -7 years with a mean unaided loss of 102 DB, were assessed on language, reading and phonological skills. Their performance was compared to that of a similar group of 32 deaf children assessed 10 years earlier, and also a group of 40 hearing children of similar single word reading ability. Results: English vocabulary was significantly higher in the new cohort, although it was still below chronological age. Phonological awareness and reading ability had not significantly changed over time. In both cohorts English vocabulary predicted reading but phonological awareness was only a significant predictor for the new cohort. Conclusions: The current results show that vocabulary knowledge of children with severe-profound hearing loss has improved over time but there has not been a commensurate improvement in phonological skills or reading. They suggest that children with severe-profound hearing loss will require continued support to develop robust phonological coding skills to underpin reading

Molecular characterization of Miraflores peach variety and relatives using SSRs

The definitive version is published in: http://www.sciencedirect.com/science/journal/03044238Some traditional peach varieties, originated from the region of Aragón (Spain), were analysed by SSRs (Simple Sequence Repeats). The aim of this research was to characterize 19 clones related to ‘Miraflores’ variety, with unknown pedigrees, to assess their genetic diversity and to elucidate their possible relationships with 10 traditional peach varieties. Twenty SSR primer pairs with high levels of polymorphism, which have been previously developed for peach, were used in this study. A total of 46 alleles were obtained for all the microsatellites studied, ranging from one to six alleles per locus, with a mean value of 2.3 alleles per locus. Fourteen SSRs were polymorphic in the set of varieties studied and permitted to distinguish 16 different genotypes out of the 30 initially studied, although fourteen ‘Miraflores’ clones showed identical gel profiles. The genetic distance matrix was used to construct Neighbor joining cluster and to perform principal coordinate analysis which allowed the arrangement of all the genotypes according to their genetic relationships. The genetic relationships among these traditional peach varieties, and in particular among ‘Miraflores’ clones are discussed. The obtained results confirm that microsatellite markers are very useful for these purposes.We are thankful to T.N. Zhebentyayeva and G.L. Reighard for helpful comments on the manuscript. This research was funded by CICYT (Comisión Interministerial de Ciencia y Tecnología, AGL2002-04219 and AGL 2005-05533), INIA (Instituto Nacional de Investigación y Tecnología Agraria y Alimentación, RF03-014-C2), Bilateral Spain-France (HF03-273) and DGA (A28, A44) projects and co-funded by the European Regional Development Fund. M. Bouhadida was supported by a fellowship from the AECI (Agencia Española de Cooperación Internacional) of the Spanish Ministry of Foreign Affairs.Peer reviewe

Seasonal effects of a hydropeaking dam on a downstream benthic macroinvertebrate community

Peer Reviewe

S100A7 and the progression of breast cancer

The S100 gene family comprises more than 20 members whose protein sequences encompass at least one EF-hand Ca(2+ )binding motif. The expression of individual family members is not ubiquitous for all tissues and there appears to be an element of tissue-specific expression. Molecular analysis of breast tumors has revealed that several S100s, including S100A2, S100A4 and S100A7, exhibit altered expression levels during breast tumorigenesis and/or progression. Subsequent studies have started to describe a functional role for these S100 proteins as well as their mechanism of action and the biochemical pathways they modify. The present review outlines what is known about S100A7 in breast cancer and summarizes the need to better understand the importance of this protein in breast cancer

Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience

Convection-enhanced delivery (CED) of highly stable PEGylated liposomes encapsulating chemotherapeutic drugs has previously been effective against malignant glioma xenografts. We have developed a novel, convectable non-PEGylated liposomal formulation that can be used to encapsulate both the topoisomerase I inhibitor topotecan (topoCED™) and paramagnetic gadodiamide (gadoCED™), providing an ideal basis for real-time monitoring of drug distribution. Tissue retention of topoCED following single CED administration was significantly improved relative to free topotecan. At a dose of 10 μg (0.5 mg/ml), topoCED had a half-life in brain of approximately 1 day and increased the area under the concentration–time curve (AUC) by 28-fold over free topotecan (153.8 vs. 5.5 μg day/g). The combination of topoCED and gadoCED was found to co-convect well in both naïve rat brain and malignant glioma xenografts (correlation coefficients 0.97–0.99). In a U87MG cell assay, the 50% inhibitory concentration (IC50) of topoCED was approximately 0.8 μM at 48 and 72 h; its concentration–time curves were similar to free topotecan and unaffected by gadoCED. In a U87MG intracranial rat xenograft model, a two-dose CED regimen of topoCED co-infused with gadoCED greatly increased median overall survival at dose levels of 0.5 mg/ml (29.5 days) and 1.0 mg/ml (33.0 days) vs. control (20.0 days; P < 0.0001 for both comparisons). TopoCED at higher concentrations (1.6 mg/ml) co-infused with gadoCED showed no evidence of histopathological changes attributable to either agent. The positive results of tissue pharmacokinetics, co-convection, cytotoxicity, efficacy, and lack of toxicity of topoCED in a clinically meaningful dose range, combined with an ideal matched-liposome paramagnetic agent, gadoCED, implicates further clinical applications of this therapy in the treatment of malignant glioma